Abstract
BACKGROUND
Photoaging, caused by long-term ultraviolet (UV) exposure, leads to wrinkles, loss of skin elasticity, pigmentation disorders, and impaired barrier function due to oxidative stress, DNA damage, and collagen breakdown. Hydrogels, with their high water content (> 90%), biocompatibility, and controlled drug release capabilities, have emerged as a powerful tool for preventing and treating skin photoaging.
AIMS
To review current treatment strategies and provide an updated perspective on the treatment of photoaging.
METHODS
We searched the PubMed and Web of Science library databases for eligible studies published within the past 5 years, categorizing and evaluating the effects of hydrogels with different carriers and active ingredients.
RESULTS
A total of 21 relevant studies were included, involving Lipid-based Hydrogels, Hyaluronic Acid-based Hydrogels, Chitosan-based Hydrogels, Polyacrylonitrile-modified κ-Carrageenan-based Hydrogels, Gellan Gum/Sodium Alginate-based Hydrogels, Recombinant Collagen-based Hydrogels, and Other Polymer-based Hydrogels.
CONCLUSIONS
The collected studies consistently demonstrate that hydrogel therapy is more effective than traditional treatments in reducing UV-induced skin damage and promoting skin repair and regeneration. In addition to improving drug utilization efficiency, hydrogel carriers-particularly those incorporating hyaluronic acid-enhance skin hydration, slow aging, and accelerate wound healing, indicating promising therapeutic potential.