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Hydrogel-Based Therapies for Photoaging: Current Advances and Future Perspectives
Qiong Gao1,2, Chenghong Xu1,2, Mingwei Tan1,2
1Center for Plastic and Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, People's Republic of China.
Journal of Cosmetic Dermatology
|June 14, 2025
Summary
Hydrogel therapy effectively treats skin photoaging by reducing UV damage and promoting skin repair. Hyaluronic acid hydrogels particularly enhance hydration and slow aging, showing significant therapeutic promise.
Area of Science:
- Dermatology
- Materials Science
- Biotechnology
Background:
- Photoaging, induced by UV radiation, causes skin aging signs like wrinkles and elasticity loss.
- Oxidative stress, DNA damage, and collagen breakdown are key mechanisms in photoaging.
- Hydrogels offer a promising solution due to their high water content, biocompatibility, and drug delivery properties.
Purpose of the Study:
- To review current treatment strategies for photoaging.
- To provide an updated perspective on hydrogel-based treatments for skin photoaging.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Inclusion of studies published within the last 5 years.
- Categorization and evaluation of hydrogels based on carriers and active ingredients.
Main Results:
- Twenty-one studies were reviewed, examining various hydrogel types (e.g., lipid-based, hyaluronic acid-based, chitosan-based).
- Hydrogel therapy demonstrated superior efficacy compared to traditional treatments in mitigating UV-induced skin damage.
- Specific hydrogels, especially those with hyaluronic acid, improved drug delivery, skin hydration, and wound healing.
Conclusions:
- Hydrogel therapy is a highly effective approach for treating photoaging and promoting skin regeneration.
- Hydrogels, particularly hyaluronic acid-based ones, offer enhanced skin hydration, anti-aging benefits, and accelerated wound healing.
- Hydrogel carriers show significant therapeutic potential for managing UV-induced skin damage.
