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Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Chang Cao1,2, Jing Yuan1, Elizabeth R Gilbert3

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Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
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PubMed
Summary
This summary is machine-generated.

Patients with Type 2 diabetes exhibit elevated levels of circulating interleukins (IL-4, IL-6, IL-17, IL-18) compared to healthy individuals. This meta-analysis confirms a systemic inflammatory response associated with Type 2 diabetes.

Keywords:
Type 2 diabetesbody mass indexinflammationinterleukinsmeta‐analysis

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Area of Science:

  • Immunology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Type 2 diabetes is a complex metabolic disorder.
  • Systemic inflammation is increasingly recognized as a contributing factor in Type 2 diabetes pathogenesis.
  • Circulating interleukin levels may serve as biomarkers for this inflammatory state.

Purpose of the Study:

  • To quantitatively evaluate circulating interleukin concentration data in patients with Type 2 diabetes.
  • To compare interleukin levels between Type 2 diabetes patients and healthy weight controls.
  • To investigate the influence of Body Mass Index (BMI) on these associations.

Main Methods:

  • Systematic review and meta-analysis of studies from PubMed, Web of Science, and Cochrane Library.
  • Inclusion of 43 studies with data from 2646 Type 2 diabetes patients and 6605 healthy weight controls.
  • Random-effects model used to calculate standardized mean differences (Hedge's g) for interleukin concentrations.

Main Results:

  • Significantly higher circulating concentrations of IL-4, IL-6, IL-17, and IL-18 were found in Type 2 diabetes patients versus controls.
  • Elevated IL-6 was observed across all BMI subgroups (obese, overweight, lean) of Type 2 diabetes patients.
  • Specific interleukins (IL-4, IL-17, IL-18) showed elevated levels in certain BMI subgroups.

Conclusions:

  • Meta-analysis confirms elevated circulating IL-4, IL-6, IL-17, and IL-18 in Type 2 diabetes patients.
  • These findings strengthen evidence for a systemic inflammatory response in Type 2 diabetes.
  • Interleukin profiles may vary based on BMI in Type 2 diabetes patients.