Predictive risk factors of recurrence in breast cancer after neoadjuvant treatment: the NEORISK study
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View abstract on PubMed
Summary
This summary is machine-generated.Neoadjuvant chemotherapy (NACT) for breast cancer (BC) can lead to recurrence. This study found that axillary staging, molecular subtype, surgery type, and nodal status after surgery predict recurrence risk in BC patients.
Area Of Science
- Oncology
- Breast Cancer Research
- Chemotherapy
Background
- Neoadjuvant chemotherapy (NACT) improves outcomes for breast cancer (BC) patients.
- Recurrence remains a significant concern despite NACT.
- Identifying factors predicting recurrence is crucial for patient management.
Purpose Of The Study
- To identify predictors of recurrence at 3 and 5 years in breast cancer patients undergoing NACT.
- To analyze factors influencing event-free survival (EFS) in this patient cohort.
Main Methods
- Retrospective analysis of 933 patients with stage I-III breast cancer.
- Data collected between 2014 and 2021.
- Multivariate analyses were used to evaluate event-free survival (EFS) predictors.
Main Results
- Lower 5-year EFS was associated with axillary staging (cN), molecular subtype, surgery type, and post-surgical nodal status (ypN).
- Aggressive tumor biology, advanced disease stage, and residual nodal burden correlated with high recurrence risk.
- Favorable treatment responses were linked to better long-term outcomes.
Conclusions
- Biological and clinical factors are key determinants of recurrence risk after NACT.
- These factors can guide the development of post-NACT strategies to minimize recurrence in high-risk breast cancer patients.
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