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Fetal NT-proBNP Concentrations in Response to Maternal Anemia: A Study of Term Pregnancies
Kadriye Erdogan1, Izzet Ozgurluk1, Dilara Kurt1
1Department of Gynecology and Obstetrics, Ankara Etlik City Hospital, Ankara, Turkey.
Objective:
This study evaluates fetal N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in umbilical cord blood from anemic versus non-anemic term pregnancies.
Materials And Methods:
In this prospective case-control study, 90 pregnant women were divided into two groups: 45 with maternal anemia and 45 without. Umbilical cord blood NT-proBNP concentrations were analyzed, and maternal data including hemoglobin and ferritin levels were collected.
Results:
NT-proBNP concentrations were significantly higher in the anemia group (844.42 ± 746.9 pg/mL vs 510.87 ± 378.52 pg/mL, p = 0.01). Maternal ferritin levels were significantly lower in the anemia group (10.02 ± 6.81 vs 37.02 ± 9.79, p < 0.001). A significant inverse relationship was found between hemoglobin and NT-proBNP concentrations (β = -76.27, p < 0.001).
Conclusion:
Elevated NT-proBNP concentrations in anemic pregnancies suggest a compensatory fetal response to hypoxia, highlighting its potential as a marker for fetal cardiovascular adaptation.
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