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Updated: Jun 16, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Diethylzinc Amylates: Selective Iodine-Zinc Exchange Reagents at Room Temperature
Florian Trauner1, Bilel Boutet1, Flavie Rambaud1
1Clemens-Schöpf-Institut für Chemie und Biochemie, Technische Universität Darmstadt, Peter-Grünberg-Straße 4, 64287 Darmstadt, Germany.
None:
The cheapest available organozinc species (diethylzinc), yet rarely employed in halogen-Zn exchange, is used in a combination with amylate salts to generate new, over time, stable reagents that allow smooth iodide-zinc exchange at room temperature, preventing therefore the need for the fastidious and time-consuming preparation of complex mixtures. The scope of the reaction has been explored on polyfunctionalized alkenes (including sensitive cyclobutenes, steroids, and glycals), aryls, and heteroaryls.
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