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Updated: Jun 16, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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Updated insights on ASK1 signaling: mechanisms, regulation, and therapeutic potential in diseases

Divyanshi Thakur1, Aniket Nandi1, Yash Kumar Gaur1

  • 1Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, 142001, India.

Molecular and Cellular Biochemistry
|June 14, 2025
PubMed

Insights

Apoptosis signal-regulating kinase 1 (ASK1) is a key kinase in cellular stress responses. Its dysregulation is linked to diseases, but inhibiting ASK1 shows therapeutic promise for oxidative stress and inflammation-driven conditions.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Biochemistry

Background:

  • Apoptosis signal-regulating kinase 1 (ASK1) is a MAP3K family member regulating cellular stress and apoptosis.
  • ASK1 activation is triggered by oxidative stress, endoplasmic reticulum stress, and inflammatory cytokines.
  • Dysfunctional ASK1 signaling contributes to neurodegenerative diseases, cardiovascular issues, cancer, and diabetes.

Purpose of the Study:

  • To review the structure, family, regulation, and dual role of ASK1 in disease.
  • To highlight ASK1's therapeutic potential in oxidative stress and inflammation-driven conditions.
  • To emphasize the need for further clinical research on ASK1 inhibition.

Main Methods:

  • Literature review of ASK1's role in cellular processes and disease.
  • Analysis of ASK1's involvement in various pathological conditions.
  • Exploration of ASK1 as a therapeutic target.

Main Results:

  • ASK1 plays a dual role in cancer, potentially initiating or suppressing it.
  • Inhibition of ASK1 shows promise in treating fibrosis and other diseases.
  • ASK1 is a significant therapeutic target for conditions driven by oxidative stress and inflammation.

Conclusions:

  • ASK1's complex role in disease necessitates further investigation.
  • Targeting ASK1 offers potential therapeutic benefits for a range of diseases.
  • Continued clinical research is crucial for translating ASK1's therapeutic potential into practice.
Keywords:
ASK SignalosomeASK1ASK2ASK3CancerDown regulatorsEtcFibrosisMAPKStructural architectUp regulators

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