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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
287
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  11. Prevalence And Clinical Significance Of Autoantibodies To Sulphite Oxidase And Glycogen Phosphorylase In Chinese Primary Biliary Cholangitis Patients

Prevalence and clinical significance of autoantibodies to sulphite oxidase and glycogen phosphorylase in Chinese primary biliary cholangitis patients

Rohil Jawed1,2

  • 1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210023, China. rohiljawed@gmail.com.

Molecular Biology Reports
|June 14, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Autoantibodies to sulphite oxidase (SUOX) and glycogen phosphorylase (PYGL) were evaluated in primary biliary cholangitis (PBC) patients. These autoantibodies lack the sensitivity and specificity for PBC diagnosis or treatment monitoring.

Area of Science:

  • Immunology
  • Hepatology
  • Autoimmunity

Background:

  • Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by the presence of specific autoantibodies.
  • Mitochondrial sulphite oxidase (SUOX) and glycogen phosphorylase (PYGL) are potential autoantigens in PBC.
  • The diagnostic and clinical significance of autoantibodies against SUOX and PYGL in Chinese PBC patients requires further investigation.

Purpose of the Study:

  • To determine the prevalence of autoantibodies to SUOX and PYGL in Chinese patients with PBC.
  • To assess the clinical significance of these autoantibodies in relation to PBC diagnosis, disease markers, and treatment response.

Main Methods:

  • Enzyme-linked immunosorbent assays (ELISA) were developed using purified SUOX and PYGL proteins.
  • Serum samples from 780 PBC patients and 352 healthy controls were analyzed for antibody detection.
Keywords:
AMAAutoantibodyM2PBC

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  • Statistical analysis correlated antibody results with clinical and biochemical data from PBC patients.

    • Main Results:

    • Autoantibodies to SUOX and PYGL were detected in 14.23% and 22.94% of PBC patients, respectively, and also in healthy controls (6.53% and 9.37%).
    • Anti-SUOX and anti-PYGL antibodies showed positive correlations with established PBC autoantibodies (anti-M2, anti-sp100, anti-gp210).
    • Antibody positivity did not correlate with response to ursodeoxycholic acid (UDCA) treatment, and titers remained unchanged before and after treatment.

    Conclusions:

    • Autoantibodies to SUOX and PYGL lack the necessary sensitivity and specificity to serve as reliable diagnostic markers for PBC.
    • Given the availability of established PBC-specific autoantibodies, anti-SUOX and anti-PYGL autoantibodies have limited value in the diagnosis and management of PBC.
    • Further research may be needed to explore other potential roles or specific patient subgroups for these autoantibodies.
    PYGL
    SUOX
    gp210
    sp100