Bioprintedin vitrotissue models: an emerging platform for developing therapeutic interventions and disease modelling

Area of Science:

• Biotechnology
• Regenerative Medicine
• Tissue Engineering

Background:

• Three-dimensional (3D) bioprinting has emerged as a key technology for developing in vitro tissue models.
• These models offer high precision in constructing functional tissues and organs for biological studies.
• 3D bioprinting extends to therapeutics, providing platforms for drug screening and disease modeling.

Purpose of the Study:

• To provide an overview of various bioprinted in vitro tissue models.
• To explore advancements in bioprinted models for therapeutic interventions.
• To discuss the application of bioprinted tissue models in drug screening and disease modeling.

Main Methods:

• Review of literature on 3D bioprinting technologies for tissue model development.
• Analysis of different biomaterials, cell sources, and bioprinting techniques.
• Detailed discussion of specific bioprinted tissue models (skin, bone, neural, vascular, cartilage, liver, cardiac).

Main Results:

• Bioprinted 3D tissue models closely mimic native tissues, surpassing conventional models.
• These models facilitate personalized drug screening and disease modeling due to high throughput and customization.
• Advancements in bioprinted models are contributing to improved therapeutic interventions.

Conclusions:

• 3D bioprinting offers significant advantages over conventional in vitro models for tissue engineering.
• Bioprinted tissue models are crucial for developing novel drug screening and disease modeling platforms.
• Addressing current challenges and future prospects will further enhance the utility of 3D bioprinted tissue models.