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Panic disorder causes an increase in choroid layer and a decrease in IPL, GCL, RNFL.

Aysun Kalenderoglu1, Aslı Egeli-Karatas2, Mehmet Hamdi Orum3

  • 1Psychiatry, Private Clinic, İzmir, Turkey.

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|June 14, 2025
PubMed
Summary
This summary is machine-generated.

Panic disorder (PD) is associated with changes in retinal layers and choroid thickness. Treatment with paroxetine and alprazolam improved retinal nerve fiber layer (RNFL) thickness in PD patients.

Keywords:
Choroidinner plexiform layeroptical coherence tomographyretinal nerve fiber layer

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Psychiatry

Background:

  • Panic disorder (PD) is a condition affecting mental health.
  • Ocular structures like the retinal nerve fiber layer (RNFL), inner plexiform layer (IPL), ganglion cell layer (GCL), and choroid thickness (CT) may be impacted by PD.

Purpose of the Study:

  • To compare ocular parameters (RNFL, IPL, GCL, CT) in PD patients before and after treatment with those in healthy controls.
  • To evaluate the effect of a four-week PD treatment regimen on these ocular parameters.

Main Methods:

  • A case-control study involving 32 PD patients and 64 healthy controls.
  • Spectral-domain optical coherence tomography (SD-OCT) was used to measure RNFL, IPL, GCL, and CT.
  • PD patients received paroxetine plus alprazolam for four weeks, with SD-OCT scans taken before and after treatment.

Main Results:

  • Pre-treatment, PD patients showed lower RNFL, GCL, and IPL values and higher CT compared to controls.
  • After four weeks of treatment, PD patients exhibited increased RNFL sub-sectors.
  • Choroid thickness (CT) demonstrated high sensitivity (71.9%) and specificity (93.8%) in diagnosing pre-treatment PD.

Conclusions:

  • Acute PD exacerbation is linked to increased CT and reduced RNFL, GCL, and IPL.
  • PD treatment positively impacts RNFL thickness.
  • SD-OCT parameters may serve as indicators for PD and its treatment response.