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Prophylactic drain placement versus non-drainage following gastric cancer surgery: A systematic review and
Ahmed Maher Khalil1, Emtenan Arishi2, Ayman Megahed3
1Maxillofacial Department, Royal Derby Hospital, Derby, UK.
Abstract:
Gastric cancer remains a significant global health burden and a leading cause of cancer-related deaths. Surgical resection is the primary curative treatment, but postoperative complications can negatively impact outcomes. Prophylactic drainage (PD) has been widely used to reduce these complications by facilitating early detection and management of fluid collections. This study evaluates the role of PD following gastric cancer surgery through a systematic review and meta-analysis of randomized controlled trials (RCTs). We searched PubMed, Web of Science, Scopus, and Cochrane databases up to January 15, 2025, and analyzed dichotomous data using risk ratio (RR) and continuous data using mean difference (MD), both with 95 % confidence intervals (CI), using R version 4.3 (PROSPERO ID: CRD42025650045). Four RCTs involving 728 patients were included. The analysis revealed that PD was associated with a significantly lower risk of mortality compared to no drainage (RR: 0.45 [95 % CI: 0.21-0.94]; P = 0.03). However, there were no significant differences between the drainage and non-drainage groups in the incidence of intra-abdominal abscess (RR: 1.23 [95 % CI: 0.49-3.06]; P = 0.66), surgical-site infection (RR: 0.93 [95 % CI: 0.56-1.52]; P = 0.76), pulmonary infection (RR: 0.66 [95 % CI: 0.37-1.18]; P = 0.16), duodenal stump leakage (RR: 1.54 [95 % CI: 0.51-4.71]; P = 0.45), anastomotic leakage (RR: 1.47 [95 % CI: 0.64-3.39]; P = 0.37), or reoperation rates (RR: 0.95 [95 % CI: 0.40-2.27]; P = 0.90). Additionally, no significant differences were observed in the length of hospital stay (MD: 0.10 [95 % CI: -0.39 to 0.58]; P = 0.70) or time to the first soft diet (MD: 0.21 [95 % CI: -0.09 to 0.50]; P = 0.17). In conclusion, PD following gastric cancer surgery is associated with a reduced risk of mortality but does not significantly impact the incidence of perioperative complications or recovery metrics. These findings suggest that while PD may offer a survival benefit, it does not appear to reduce common postoperative complications or accelerate recovery.
