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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Value Analysis Of Preoperative Peripheral Blood Markers In The Identification Of Benign From Malignant Parotid Gland Tumors

Value Analysis of Preoperative Peripheral Blood Markers in the Identification of Benign From Malignant Parotid Gland Tumors

Zheng Ye1, Hui Dong1, Fuyong Sui1

  • 1Department of Oral and Maxillofacial Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

International Dental Journal
|June 14, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Preoperative blood tests like total protein and albumin-to-globulin ratio can help distinguish benign from malignant parotid tumors. These inflammatory and nutritional markers offer a potential new diagnostic approach for parotid gland tumors.

Area of Science:

  • Oncology
  • Biochemistry
  • Diagnostic Medicine

Background:

  • Parotid gland tumors present a diagnostic challenge, with benign and malignant types requiring different management strategies.
  • Accurate preoperative differentiation is crucial for effective treatment planning and patient outcomes.

Purpose of the Study:

  • To evaluate the utility of preoperative peripheral blood inflammatory and nutritional parameters in differentiating benign from malignant parotid gland tumors.
  • To identify specific biomarkers that can aid in the diagnosis of parotid malignancies.

Main Methods:

  • A retrospective analysis of 158 patients (79 benign, 79 malignant parotid tumors) was performed.
  • Preoperative levels of total protein (TP), prealbumin (PA), albumin (Alb), albumin-to-globulin ratio (AGR), apolipoprotein A1-to-apolipoprotein B ratio (ApoA1/ApoB), and platelet-to-lymphocyte ratio (PLR) were assessed.
Keywords:
AlbuminParotid tumorsPeripheral bloodPlatelet-to-lymphocyte ratio

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  • Statistical analysis, including binary logistic regression, was used to determine diagnostic value.

    • Main Results:

    • Malignant parotid tumors showed significantly higher ApoA1/ApoB ratios and PLR compared to benign tumors (P < .05).
    • TP, PA, Alb, and AGR were significantly lower in the malignant group (P < .05).
    • TP, PA, AGR, and ApoA1/ApoB were identified as independent risk factors for parotid malignancy, with established optimal cut-off values.

    Conclusions:

    • Preoperative inflammatory and nutritional markers show promise as adjunctive tools for distinguishing benign from malignant parotid gland tumors.
    • These blood parameters could potentially improve preoperative diagnostic accuracy for parotid tumors.
    • Further large-scale research is necessary to validate these findings and clinical utility.
    Total protein