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Updated: Dec 26, 2025

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
Published on: November 15, 2024
Effects of high-definition transcranial direct current stimulation (HD-tDCS) on resting brain functional connectivity
Rujuta Parlikar1, Harleen Chhabra1, Sowmya Selvaraj1
1Department of Psychiatry, National Institute of Mental Health And Neurosciences, Bengaluru, India.
Abstract:
High-definition transcranial Direct Current Stimulation (HD-tDCS) is an emerging neuromodulation technique for treating auditory verbal hallucinations (AVH) in schizophrenia (SZ) that do not respond adequately to psychotropic treatments. We are unaware of any functional Magnetic Resonance Imaging (fMRI) study examining the neural effect of HD-tDCS on AVH in SZ. In this study, we examined the effect of MRI-neuronavigated HD-tDCS on functional brain connectivity using fMRI in SZ patients (N = 34) with persistent AVH. HD-tDCS was delivered in a double-blind, randomized, parallel-arm, sham-controlled design (5 days of twice daily, 20-minute sessions). The resting-state fMRI data was acquired using a 3 T scanner. Active HD-tDCS treatment, in comparison to the sham, resulted in significant changes in the resting-state functional connectivity involving Heschl's gyrus, temporoparietal junction, caudate nucleus, precuneus, lateral occipital cortex, and hippocampus. Our study shows that HD-tDCS causes brain connectivity changes in regions implicated in AVH pathogenesis in SZ.
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15:05Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation HD-tDCS
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