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Autophagy-related myosins: Critical roles and potential therapeutic effects in malignancies

Jiaying Xiong1, Xin Wen2, Meiyan Chen2

  • 1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|June 14, 2025
PubMed

Insights

Myosins are motor proteins that regulate cell structure and function. This review explores how myosins influence autophagy in cancer, offering potential therapeutic strategies for tumor treatment.

Area of Science:

  • Molecular biology
  • Cell biology
  • Cancer research

Background:

  • Myosins are actin-based motor proteins crucial for cellular processes.
  • Autophagy maintains cellular homeostasis by degrading cytoplasmic components.
  • Myosin's role in autophagy is increasingly recognized in cancer development.

Purpose of the Study:

  • To review the multifaceted roles of myosins in autophagy.
  • To elucidate how myosins impact cancer progression through autophagy.
  • To explore potential therapeutic strategies targeting myosin-mediated autophagy.

Main Methods:

  • Literature review of existing research on myosins, autophagy, and cancer.
  • Analysis of myosin functions across different stages of autophagy.
  • Examination of myosin's influence on tumor microenvironment and immune cells.

Main Results:

  • Myosins regulate key steps in the autophagy pathway.
  • Myosin-mediated autophagy affects tumorigenesis, cell migration, and signaling.
  • Dysregulation of myosins and autophagy contributes to cancer progression.

Conclusions:

  • Myosins are critical regulators of autophagy in cancer.
  • Targeting myosin-autophagy interactions presents a promising therapeutic avenue.
  • Further research into myosin-autophagy pathways could yield novel cancer treatments.
Keywords:
AutophagyCancer therapyMyosinsTumorigenesis

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