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  1. Home
  3. Comprehensive Lipid Metabolites-pyroptosis Profiling Uncovers The Therapeutic Efficacy Of Mailuo Shutong Pill Against Thromboangiitis Obliterans.
  1. Home
  3. Comprehensive Lipid Metabolites-pyroptosis Profiling Uncovers The Therapeutic Efficacy Of Mailuo Shutong Pill Against Thromboangiitis Obliterans.

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Comprehensive lipid metabolites-pyroptosis profiling uncovers the therapeutic efficacy of Mailuo Shutong pill against

Chenhan He1, Peipei Zhou1, Zhibo Zhang1

  • 1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Henan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, 450052, China.

Journal of Ethnopharmacology
|June 14, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Mailuo Shutong pill (MLSTP) treats thromboangiitis obliterans (TAO) by restoring lipid balance and inhibiting pyroptosis. This study reveals MLSTP’s mechanisms, offering new insights into TAO treatment.

Keywords:
GSDMELipidomicsMailuo Shutong pillPyroptosisThromboangiitis obliterans

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Traditional Chinese Medicine

Background:

  • Thromboangiitis obliterans (TAO) is characterized by vascular inflammation and necrosis.
  • Mailuo Shutong pill (MLSTP), a traditional Chinese medicine, is clinically used for TAO but its mechanism is unclear.

Purpose of the Study:

  • To elucidate the mechanism of MLSTP in treating sodium laurate-induced thromboobliteration.
  • Utilize lipidomics and bioinformatics to analyze MLSTP's effects.

Main Methods:

  • Identify MLSTP compounds using UHPLC-Q-Orbitrap-HRMS.
  • Evaluate MLSTP's efficacy in a TAO rat model via clinical and pathological assessments.
  • Employ lipidomics for biomarker discovery and bioinformatics for pathway analysis.
  • Verify findings with immunohistochemistry.

Main Results:

  • MLSTP demonstrated vasoprotective effects in TAO rats.
  • Identified differential metabolites linked to sphingolipid, glycerolipid, linoleic acid, and alpha-linolenic acid metabolism.
  • Bioinformatics predicted pyroptosis pathways associated with sphingolipid metabolism, involving CerS1, CASP8/CASP3/GSDME, and inflammatory cytokines.
  • Integrated analyses revealed MLSTP's multi-target action on lipid metabolism and pyroptosis.

Conclusions:

  • MLSTP alleviates TAO by correcting lipid homeostasis and inhibiting pyroptosis.
  • The study provides novel mechanistic insights into MLSTP's therapeutic action for TAO.