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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
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Conduction System of the Heart01:19

Conduction System of the Heart

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Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
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Chambers of the Heart01:16

Chambers of the Heart

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The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Evolutionary Biology
  9. Speciation And Extinction
  11. The Senescent Heart And Atrial Fibrillation.
  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Evolutionary Biology
  9. Speciation And Extinction
  11. The Senescent Heart And Atrial Fibrillation.

Related Experiment Video

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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The senescent heart and atrial fibrillation.

Amitabh C Pandey1, Ghassan Bidaoui2, Hadi Younes2

  • 1Department of Cardiology, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana; Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana.

Heart Rhythm
|June 14, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Cellular senescence, a hallmark of aging, contributes to atrial myopathy and atrial fibrillation (AF). This review explores the link between aging, cardiac senescence, and AF, discussing potential senolytic and senomorphic therapies.

Keywords:
AgingAtrial fibrillationAtrial fibrosisAtrial myopathy

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
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Related Experiment Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
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Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

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Area of Science:

  • Cardiology
  • Gerontology
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) prevalence is rising globally, driven by population aging.
  • Aging contributes to atrial myopathy, the substrate for AF, but mechanisms are unclear.
  • Cellular senescence, a key aging process, is implicated in aging-related diseases.

Purpose of the Study:

  • To review the molecular basis of cardiac senescence and its secretory phenotype.
  • To explore the relationship between cardiac senescence, atrial myopathy, and AF.
  • To discuss senolytic and senomorphic agents for AF treatment.

Main Methods:

  • Literature review of cardiac senescence and AF.
  • Analysis of molecular pathways linking senescence to atrial remodeling.
Senescence
  • Examination of pre-clinical studies on senotherapies in cardiology.

    • Main Results:

    • Cellular senescence, with its unique secretome, contributes to atrial myopathy.
    • Renin-angiotensin-aldosterone system activation, mitochondrial dysfunction, and epigenetic changes are involved.
    • Senolytic and senomorphic agents show potential in pre-clinical models.

    Conclusions:

    • Cellular senescence is a critical factor in age-related atrial myopathy and AF.
    • Targeting senescence pathways offers a promising therapeutic strategy for AF.
    • Further research is needed to translate senotherapies into clinical practice for AF.