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Oogenesis02:07

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Risk Of Ovarian Cancer In Women With Pelvic Inflammatory Disease And Homologous Recombination Repair Gene Mutations Under 55: A Population-based Cohort Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Risk Of Ovarian Cancer In Women With Pelvic Inflammatory Disease And Homologous Recombination Repair Gene Mutations Under 55: A Population-based Cohort Study.

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In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
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Risk of ovarian cancer in women with pelvic inflammatory disease and homologous recombination repair gene mutations under 55: a population-based cohort study.

Chenzhao Feng1,2, Wanwan Luo1,2, Zanhong Wang3

  • 1Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Gynecologic Oncology
|June 14, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Ovarian CancerPelvic Inflammatory DiseaseRecombinational DNA RepairUK Biobank

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Pelvic inflammatory disease (PID) is linked to increased ovarian cancer (OC) risk, especially in women under 55. Those with PID and genetic mutations face the highest OC risk, suggesting PID may be a precursor.

Area of Science:

  • Gynecologic Oncology
  • Epidemiology
  • Genetics

Background:

  • Pelvic inflammatory disease (PID) is a significant gynecologic infection.
  • Ovarian cancer (OC) risk is influenced by various factors, including genetic predisposition.
  • The interplay between PID, genetic vulnerability, and OC risk requires further investigation.

Purpose of the Study:

  • To investigate the association between a history of PID and the risk of developing OC.
  • To explore the combined effect of PID and germline homologous recombination repair (gHR) mutations on OC risk.
  • To analyze these associations within different age groups using UK Biobank data.

Main Methods:

  • Prospective cohort study utilizing UK Biobank data.
  • Tracking OC incidence in individuals with and without a history of PID.
  • Identification of gHR mutations (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1) using whole-exome sequencing.
  • Cox regression models were employed to assess hazard ratios (HRs) for OC risk.

    • Main Results:

    • A history of PID was associated with a 1.45-fold increased risk of OC (HR=1.45, 95% CI=0.90, 2.32).
    • The association was more pronounced in women under 55 years old (HR=1.92, 95% CI=1.02, 3.63).
    • Individuals under 55 with both PID history and gHR mutations showed the highest OC risk (HR=7.40, 95% CI=1.03, 53.10).

    Conclusions:

    • PID is associated with an increased risk of ovarian cancer, particularly in women under 55.
    • The combination of PID history and germline homologous recombination repair mutations significantly elevates OC risk.
    • Findings suggest PID may act as a precursor for OC, highlighting the need for early intervention in high-risk individuals, especially younger women with gHR mutations.