Predictors of Hypocalcemia Post Parathyroidectomy for Primary Hyperparathyroidism; a Single Center Study

Area of Science:

• Endocrinology
• Surgical Oncology
• Neurosurgery

Background:

• Hypocalcemia is a frequent complication following parathyroidectomy for primary hyperparathyroidism (PHPT).
• Identifying risk factors and predictive biomarkers for postoperative hypocalcemia is crucial for patient management.

Purpose of the Study:

• To determine the incidence of hypocalcemia after parathyroidectomy in PHPT patients.
• To identify preoperative risk factors and serum biomarkers associated with the development of hypocalcemia.

Main Methods:

• Retrospective study of 116 patients undergoing parathyroidectomy for PHPT.
• Postoperative hypocalcemia defined as serum calcium < 2.15 mmol/L within the first week.
• Logistic regression and ROC curve analysis used to identify predictors and cutoffs.

Main Results:

• Hypocalcemia occurred in 57.7% of patients post-parathyroidectomy.
• Higher preoperative alkaline phosphatase (ALP), lower preoperative corrected calcium, higher preoperative parathyroid hormone (PTH), and younger age were associated with hypocalcemia.
• Low preoperative corrected calcium and high preoperative ALP were independent predictors of hypocalcemia.

Conclusions:

• Preoperative ALP, preoperative corrected calcium, preoperative PTH, and younger age are significant risk factors for postoperative hypocalcemia.
• Preoperative ALP and corrected calcium levels are independent predictors, aiding in risk stratification.