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Updated: Jun 16, 2025

Murine Flexor Tendon Injury and Repair Surgery
Published on: September 19, 2016
Structure Function Relationships in the Aging Superficial Digital Flexor Tendon: Implications for Injury
Danae E Zamboulis1, Chavaunne T Thorpe2
1Department of Clinical Sciences, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.
Abstract:
The high stresses and strains experienced by the superficial digital flexor tendon (SDFT) make it prone to age-related injury. The SDFT exhibits cellular and structural specializations, localized to the interfascicular matrix (IFM), enabling it to resist its extreme mechanical environment. With aging, these specializations are lost, impacting the ability of the tendon to withstand repeated loading. Within the IFM, there is loss of mechanical properties and organization accompanying cell senescence and a decreased resolution of inflammation. Developing therapeutics to reverse these changes may, therefore, provide preventative measures and therapeutics for SDFT injury.
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