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  9. Medical Virology
  11. Monkeypox Virus And Type 1 Diabetes: A Molecular Insight Into Inflammatory Signaling And Β-cell Autoimmunity

Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

Yahya A Almutawif1, Haydar M Al-Kuraishy2, Ali I Al-Gareeb3

  • 1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia.

Virology Journal
|June 14, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Monkeypox virus (MPXV) infection may trigger autoimmune responses, potentially leading to type 1 diabetes (T1D). Further research is needed to confirm this link and understand MPXV

Area of Science:

  • Virology
  • Immunology
  • Endocrinology

Background:

  • The global monkeypox (MPXV) outbreak raises concerns about potential long-term health effects.
  • Emerging evidence suggests a possible link between MPXV infection and the development of autoimmune diseases, including type 1 diabetes (T1D).

Purpose of the Study:

  • To analyze potential mechanisms by which MPXV infection could induce autoimmune responses.
  • To investigate the possible damage to pancreatic β-cells following MPXV infection.
  • To explore MPXV-induced immune dysregulation and inflammation contributing to T1D development.

Main Methods:

  • Review of published literature on MPXV, autoimmune disorders, and type 1 diabetes.
  • Analysis of potential viral mechanisms implicated in other diabetogenic viruses (enterovirus, SARS-CoV-2).
Keywords:
AutoimmunityCOVID-19CytokinesDiabetogenic viruses

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  • Examination of immune dysregulation and inflammatory pathways.

    • Main Results:

    • The association between MPXV and T1D is currently limited in published data.
    • Potential pathways for MPXV to trigger autoimmune reactions and damage pancreatic β-cells are proposed.
    • Insights from other diabetogenic viruses suggest possible parallels.

    Conclusions:

    • MPXV infection may represent a novel risk factor for type 1 diabetes.
    • Further comprehensive studies are essential to establish a definitive causal relationship between MPXV and T1D.
    • Understanding these mechanisms is crucial for public health preparedness.
    Immune dysregulation
    Inflammation
    Monkeypox
    Pancreatic β-cells
    Type 1 diabetes
    Viral infections