Related Experiment Video
Updated: Sep 19, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
Evolution of TROP2: Biological insights and clinical applications
Xinyue Zhang1, Hong Xiao1, Fangjian Na2
1Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, 110001, China.
Abstract:
Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein that is overexpressed in a wide range of cancers and is associated with poor prognosis and aggressive tumor behavior. This review synthesizes current research on the function of TROP2 in cancer progression through bibliometric analysis, with a special emphasis on advances in the study of antibody-drug conjugates (ADCs) targeting TROP2. We examine the efficacy of targeted therapies against TROP2, in particular the use of sacituzumab govitecan (SG), and evaluate their clinical impact on the treatment of various cancers. Through recent studies and clinical trials, we analyze the clinical effects of TROP2-ADCs and explored the prospects for their application in different cancers, including combination therapies with other therapeutic approaches, studies of resistance mechanisms, and further exploration of TROP2 as a biomarker. This review aims to provide a concise overview of TROP2 applications in cancer therapy, emphasizing emerging trends and therapeutic strategies to provide direction for future research and clinical practice.
Related Concept Videos
Transduction
Eukaryotic Evolution
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Gene Duplication and Divergence
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
Synteny and Evolution
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Evolutionary Psychology
Preclinical Development: Overview

