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Updated: Sep 19, 2025

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
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P-selectin and E-selectin: Key macromolecules in thrombus formation and resolution

Richa Yadav1, Kajal Kumari1, Radhika Joshi2

  • 1Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.

International Journal of Biological Macromolecules
|June 15, 2025
PubMed

Insights

Early deep vein thrombosis (DVT) detection is improved using P- and E-selectins as biomarkers. Selectin-targeted imaging offers non-invasive, real-time thrombus visualization for enhanced diagnosis and potential therapeutic strategies.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Molecular Diagnostics

Background:

  • Deep vein thrombosis (DVT) is a significant cause of mortality and morbidity.
  • Current diagnostic methods for DVT lack optimal sensitivity and specificity due to non-specific symptoms and limited objective findings.

Purpose of the Study:

  • To review the role of P- and E-selectins in thrombosis.
  • To explore the utility of selectins as diagnostic biomarkers and molecular imaging agents for DVT.
  • To assess the potential of selectin-targeted imaging for early and accurate DVT detection.

Main Methods:

  • Review of literature on selectins (P- and E-selectins) in the context of thrombosis.
  • Investigation of selectin-targeted molecular imaging techniques, including PET and SPECT.
  • Analysis of selectins' role in thrombus formation, resolution, and recurrence.

Main Results:

  • P- and E-selectins are implicated in thrombus formation and inflammation, showing potential as early DVT biomarkers.
  • Combined selectin-targeted PET and SPECT imaging enables real-time, non-invasive thrombus detection, potentially surpassing conventional methods.
  • Selectin-based diagnostics can enhance the sensitivity and specificity of DVT detection.

Conclusions:

  • Selectin-targeted imaging presents a promising approach for early and accurate diagnosis of deep vein thrombosis.
  • Further research is needed to refine imaging techniques, improve selectin measurement specificity, and develop targeted therapies.
  • Selectin-based diagnostics and therapeutics hold potential for personalized treatment protocols and improved patient outcomes in DVT management.

Keywords:
BiomarkersMolecular imagingNon-invasive imagingP & E selectinThrombosis

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