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Updated: Sep 19, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
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IKZF1: An important target for the treatment of autoimmune diseases

Siyuan Bu1, Cong Ye1, Shaozhe Cai1

  • 1Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Clinical Immunology (Orlando, Fla.)
|June 15, 2025
PubMed

IKZF1 is a member of the Ikaros transcription factor family. It is involved in the regulation of the development and function of a variety of immune cells. Mutations or aberrant expression of IKZF1 are closely associated with the development of various immune-related diseases, including hematologic malignancies, solid tumors, and autoimmune diseases. In recent years, more and more studies have revealed the important role of IKZF1 in regulating immune responses, maintaining immune tolerance, and inhibiting the overactivation of immune cells. What's more, IKZF1 has been discovered to have a significant connection to the pathogenesis of autoimmune diseases. This review will summarize the role of IKZF1 in autoimmune diseases and its potential clinical applications.

Keywords:
Autoimmune diseasesB cellIKZF1T cellThalidomide

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