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[Pathology of the blood microcirculation in congenital heart defects with a right-to-left shunt]
Insights
Congenital heart disease in infants alters omental microcirculation, causing blood flow issues like aggregation and stasis. These changes worsen with heart decompensation, impacting circulation and venous congestion.
Area of Science:
- Pediatric Pathology
- Cardiovascular Physiology
- Microcirculation Research
Abstract:
The alterations of the microcirculatory bed of the greater omentum in 17 children dying within the first year of life from congenital heart disease with the blood effluent from the right to the left are described. Pathological and compensatory changes are revealed in the microvessels and their functional significance is shown. The dependence of hemorheological disturbances in the microcirculatory bed (blood cell aggregation, local blood stasis, intravascular coagulation) upon the degree of heart decompensation followed by the slowing down of the circulation and increasing of the congestion in the venous system is pointed out.