Correlation Between the J-MACS, HeartMate3, and J-HeartMate Risk Scores and Their Prognostic Impact in Japanese...

In addition to the J-HeartMate Risk Score (J-HMRS) and HeartMate 3 Risk Score (HM3RS), the J-MACS Risk Score (J-MACS-RS) was developed to predict death after left ventricular assist device (LVAD) implantation in Japanese patients with heart failure (HF). However, the correlation between these scores, the characteristics of high-risk patients as per these scores, and the mortality stratification of these scores in HF patients regardless of LVAD implantation are still not fully understood.

Hospitalized patients with HF who underwent echocardiography and right heart catheterization were included (n=269). Patients at low or medium risk per the J-HMRS or HM3RS and at high risk per the J-MACS-RS (LM_J-HMH_J-MACS and LM_HM3H_J-MACS, respectively) were compared with those at low or medium risk per both scores (LM_J-HMLM_J-MACSand LM_HM3LM_J-MACS, respectively). The J-MACS-RS was well associated with the J-HMRS (r=0.66) and HM3RS (r=0.65). Patients with LM_J-HMH_J-MACS were older and showed a higher prevalence of ischemic etiology and history of cardiac surgery than those with LM_J-HMLM_J-MACS. LM_J-HMH_J-MACS and LM_HM3H_J-MACSshowed higher serum creatinine levels and central venous pressure-to-pulmonary artery wedge pressure ratios than LM_J-HMLM_J-MACSand LM_HM3LM_J-MACS, respectively. All scores stratified the 3-year mortality in patients with HF.

The J-MACS-RS correlated well with the J-HMRS and HM3RS. These scores may predict 3-year mortality, even in Japanese HF patients, regardless of LVAD implantation.