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The association between the systemic inflammation response index and overactive bladder: a cross-sectional study
Liandong Chen1, Xier Xu2, Yidong Zhou3
1The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
European Journal of Medical Research
|June 15, 2025
Summary
Systemic Inflammation Response Index (SIRI) is a significant risk factor for overactive bladder (OAB). Higher SIRI levels correlate with increased OAB symptom severity, highlighting inflammation
Area of Science:
- Urology
- Inflammation research
- Public health
Background:
- Overactive bladder (OAB) pathophysiology remains unclear regarding inflammation.
- The Systemic Inflammation Response Index (SIRI) quantifies systemic inflammatory status.
- This study investigates SIRI's association with OAB risk and severity (OABSS).
Purpose of the Study:
- To assess the relationship between SIRI and the risk of developing OAB.
- To determine the association between SIRI and the severity of OAB symptoms.
- To explore potential nonlinear relationships and subgroup consistencies.
Main Methods:
- Utilized National Health and Nutrition Examination Survey (NHANES) data (2005-2020).
- Employed weighted logistic and linear regression models to analyze SIRI's impact on OAB risk and OABSS.
- Applied restricted cubic spline (RCS) models for nonlinear analysis and conducted subgroup analyses.
Main Results:
- Analysis included 23,915 individuals; 21% (9011) had OAB.
- Significant positive associations found between SIRI and OAB risk (OR=1.268) and severity (β=0.143).
- RCS models confirmed a nonlinear relationship; subgroup analyses supported consistency across populations.
Conclusions:
- SIRI is a significant risk factor for overactive bladder.
- Elevated SIRI levels are strongly linked to increased OAB symptom severity.
- Findings underscore the role of systemic inflammation in OAB.
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