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Updated: Sep 19, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Published on: June 28, 2019
[Functional Neurological Disorder for Neurologists]
1Department of General Internal Medicine and Clinical Laboratory, National Center of Neurology and Psychiatry National Center Hospital.
Functional neurological disorders (FND) are increasingly diagnosed using positive signs, not exclusion. Neurologists can detect these signs, especially in functional movement disorders, aiding accurate FND diagnosis and treatment.
Area of Science:
- Neurology
- Neuroscience
Background:
- Functional neurological disorders (FND) are common in neurological clinics.
- The diagnostic approach has evolved from exclusion to positive diagnosis using specific signs.
- Psychological stressors are recognized as key risk factors for FND.
Purpose of the Study:
- To highlight the shift towards positive diagnosis in FND.
- To emphasize the role of "positive signs" in diagnosing FND.
- To discuss the importance of recognizing subtypes and their shared pathophysiology.
Main Methods:
- Review of current diagnostic approaches for FND.
- Identification and discussion of "positive signs" for FND diagnosis.
- Focus on functional movement disorders and newly reported diagnostic signs.
Main Results:
- Positive signs, indicating incompatibility, are central to modern FND diagnosis.
- Functional movement disorders offer readily detectable positive signs.
- New diagnostic signs reported by Japanese neurologists can enhance FND diagnosis.
Conclusions:
- Neurologists are crucial for diagnosing and treating FND.
- The adoption of positive signs facilitates a more accurate and timely FND diagnosis.
- Effective utilization of positive signs, particularly for functional movement disorders, is recommended.
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