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Updated: Sep 19, 2025

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
[Autoimmune Encephalitis Centered on NMDAR Encephalitis from a Psychiatrist's Perspective]
Manabu Takaki1, Shinji Sakamoto
1Department of Neuropsychiatry, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences.
Abstract:
Autoimmune encephalitis, within the psychiatric domain, encompasses two concepts involving psychiatric symptoms triggered by cell-membrane surface antibodies: NMDAR encephalitis, which manifests as encephalitis in neurology, and neuronal autoantibodies detected predominantly in the serum of patients with schizophrenia. Autoimmune encephalitis is associated with humoral immunity abnormalities caused by autoantibodies in the acute phase and cell-mediated immunity disruptions, including those in the chronic phase. Follow-up knowledge is required to provide evidence for immunotherapy in patients with mental illnesses.
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