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Related Experiment Video

Updated: Sep 19, 2025

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Development of a Flexible Electrode for Electrical Stimulation of Rabbit Extraocular Muscle.

Hee Kyung Yang1, Lee-Woon Jang2, Dong Hyun Kim1

  • 1Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Korean Journal of Ophthalmology : KJO
|June 16, 2025
PubMed
Summary

A novel flexible electrode successfully elicited eye movement via direct electrical stimulation of extraocular muscles in rabbits. This safe method showed no ocular damage, offering potential for future applications.

Keywords:
Electrical stimulationExtraocular muscleFlexible electrodeHistologic examination

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Area of Science:

  • Biomedical Engineering
  • Ophthalmology
  • Neuroscience

Background:

  • Developing effective methods for controlling eye movements is crucial for treating various ocular motility disorders.
  • Flexible electrodes offer potential for minimally invasive neural and muscular stimulation.

Purpose of the Study:

  • To create a flexible electrode for electrical stimulation of extraocular muscles.
  • To assess the safety and efficacy of direct electrical stimulation on rabbit ocular tissues.

Main Methods:

  • Fabrication of a flexible electrode using photolithography with platinum and polyimide.
  • In vivo study in rabbits involving electrical stimulation of superior and inferior rectus muscles over 4 weeks.
  • Histological examination of ocular tissues including conjunctiva, muscles, sclera, and retina.

Main Results:

  • Successful elicitation of eye movement in rabbits through direct electrical stimulation of extraocular muscles.
  • Histological analysis revealed no detrimental effects from the electrical stimulation procedure.

Conclusions:

  • Direct electrical stimulation using a flexible electrode is a safe method for eliciting eye movement in rabbits.
  • The developed electrode technology shows promise for applications in ocular motility control without causing ocular damage.