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Regular meals matter: bone growth and beyond.

Rhonda D Kineman1,2, Shoshana Yakar3

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Three meals a day enhance bone growth in young males by stimulating ghrelin and growth hormone release. This effect on skeletal accrual depends on the ghrelin signaling system for optimal bone health.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Nutritional Science

Background:

  • The impact of dietary patterns on growth is not fully understood.
  • Investigating the relationship between meal timing and physiological responses is crucial for understanding growth mechanisms.

Purpose of the Study:

  • To investigate how confining food intake to discrete meals affects growth markers in young males.
  • To determine the role of the ghrelin signaling system in mediating the effects of meal patterns on bone growth.

Main Methods:

  • Observational study in young males tracking food intake patterns.
  • Measurement of preprandial ghrelin release and postprandial growth hormone pulse release.
  • Assessment of epiphysial plate expansion as an indicator of bone growth.

Main Results:

  • Confining food intake to three meals daily entrained preprandial ghrelin release.
  • This pattern led to postprandial growth hormone pulses associated with increased epiphysial plate expansion.
  • The positive effects on bone growth were dependent on an intact ghrelin signaling system.

Conclusions:

  • Meal-entrained ghrelin release may enhance skeletal accrual through hormonal signaling.
  • Coordinating hormonal cues with food intake could optimize bone acquisition and long-term bone health.
  • Understanding these mechanisms can inform strategies for improving bone health across the lifespan.