Interferon-Stimulated Genes: Novel Targets in Renal Pathogenesis
Meng Jia1, Shuangxu Han2, Liang Li3
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kidney Diseases (Basel, Switzerland)
|June 16, 2025
Summary
Interferons (IFNs) impact kidney diseases by activating interferon-stimulated genes (ISGs). Understanding these pathways is key to developing new diagnostics and therapies for renal disorders.
Area of Science:
- Immunology
- Nephrology
- Molecular Biology
Background:
- Kidney diseases pose a significant global health challenge with limited effective treatments.
- Novel biomarkers, early diagnostics, and therapeutic targets are crucial for managing renal disorders.
- Interferons (IFNs) are cytokines vital for immune responses, including antiviral and antiproliferative activities.
Purpose of the Study:
- To review the role of interferon-related genes in kidney diseases.
- To explore the mechanisms of interferon signaling in renal disorders.
- To discuss therapeutic strategies and consequences of enhanced interferon signaling in the kidney.
Main Methods:
- Literature review focusing on interferon signaling and kidney diseases.
- Analysis of the impact of interferon-stimulated genes (ISGs) in renal pathophysiology.
- Examination of current and emerging therapeutic approaches targeting ISGs.
Main Results:
- IFNs induce ISGs, which are critical for immune regulation and viral control.
- Enhanced interferon signaling can contribute to the development and progression of kidney diseases.
- Current diagnostic and therapeutic strategies targeting ISGs are not yet clinically implemented.
Conclusions:
- A deeper understanding of ISG-regulated pathophysiology is needed for kidney disease management.
- Advances in understanding interferon pathways offer potential for novel ISG-based diagnostics and therapies.
- Clinical translation of ISG-based interventions holds promise for treating renal disorders.
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