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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Engineering microneedles for biosensing and drug delivery.

Penghui Zhao1, Zerui Zhou1, Tyler Wolter2

  • 1Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.

Bioactive Materials
|June 16, 2025
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Summary

Microneedles (MNs) offer a minimally invasive way to deliver drugs or collect bio-fluids. Ongoing research focuses on enhancing their biosensing capabilities and drug delivery efficiency for future clinical use.

Keywords:
BiosensingClinical translationDrug deliveryMicroneedle

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Microneedles (MNs) are small, minimally invasive devices used for bio-fluid collection and therapeutic agent delivery.
  • Their small size and reduced invasiveness can improve patient compliance, especially for those with needle phobia.
  • Current research aims to overcome technical challenges and advance MNs toward clinical applications.

Purpose of the Study:

  • To explore engineering methods for microneedle (MN) fabrication.
  • To focus on the integration of biosensing capabilities and drug delivery functionalities in MNs.
  • To review clinically approved MN designs and identify future development opportunities.

Main Methods:

  • Review of microneedle (MN) designs, materials, and fabrication techniques.
  • Analysis of methods for integrating biosensors for real-time analyte monitoring.
  • Examination of strategies to enhance drug delivery efficiency, stability, and patient comfort.
  • Investigation of clinically approved MN designs for translational insights.

Main Results:

  • Microneedles (MNs) show promise for enhanced drug delivery and real-time biosensing.
  • Various designs, materials, and fabrication methods are being explored to optimize MN performance.
  • Clinically approved MN designs provide valuable insights for future development.

Conclusions:

  • Microneedle (MN) technology is rapidly evolving, with significant potential in biosensing and drug delivery.
  • Continued research is crucial to address technical obstacles and facilitate clinical translation.
  • Future opportunities lie in refining MN designs for improved efficacy, stability, and patient experience.