Infectious Mononucleosis Causing Bell's Palsy: A Case Report

Roopin P Singh1, William Parker2, Gowrish Vaka1

  • 1Medicine, Edward Via College of Osteopathic Medicine, Monroe, USA.

Cureus
|June 16, 2025
PubMed

Insights

Infectious mononucleosis, caused by Epstein-Barr virus, can rarely lead to Bell's palsy. This case report details a young woman experiencing facial paralysis as a neurological complication of mononucleosis.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Infectious mononucleosis, commonly known as mono, is a viral illness typically caused by the Epstein-Barr virus (EBV).
  • It presents with symptoms such as fever, swollen lymph nodes (lymphadenopathy), and throat inflammation (pharyngitis).
  • Bell's palsy is characterized by sudden, unilateral facial weakness or paralysis with diverse potential causes.

Observation:

  • This report focuses on an 18-year-old female patient.
  • The patient was diagnosed with Bell's palsy, a condition affecting facial nerve function.
  • This diagnosis was linked to Epstein-Barr virus-associated infectious mononucleosis.

Findings:

  • The case highlights Bell's palsy as a rare neurological complication of infectious mononucleosis.
  • Facial nerve palsy is an atypical manifestation in patients with Epstein-Barr virus-induced mononucleosis.
  • This presentation underscores the varied neurological sequelae of EBV infection.

Implications:

  • This case expands the understanding of potential neurological complications associated with Epstein-Barr virus.
  • It emphasizes the importance of considering infectious mononucleosis in the differential diagnosis of Bell's palsy, especially in young adults.
  • Further research may elucidate the specific mechanisms linking EBV to facial nerve dysfunction.

Related Concept Videos

Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
187
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
217
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
31
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
30