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Updated: Sep 19, 2025

Waste Water Derived Electroactive Microbial Biofilms: Growth, Maintenance, and Basic Characterization
Published on: December 29, 2013
Microbial electrosynthesis meets synthetic biology: Bioproduction from waste feedstocks
Dijin Zhang1,2,3,4, Jee Loon Foo1,2,3,4, Matthew Wook Chang1,2,3,4
1NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore.
Abstract:
Integrating electrochemistry and biology, microbial electrosynthesis (MES) enhances feedstock-to-product conversion by utilizing electroactive microorganisms to harness electrical energy for driving metabolic pathways. Advances in synthetic biology have improved microbial extracellular electron transfer and increased metabolic pathway efficiency, enabling optimized redox balance, expanded substrate versatility and enhanced bioproduction. Given the growing interest in sustainable chemical production and decarbonization, this mini-review highlights recent progress in MES enabled by synthetic biology, with a focus on engineering efficient microbial cell factories for electricity-mediated bioproduction through waste-derived feedstock utilization and carbon capture. We also highlight key challenges limiting MES scalability and propose future directions to enable industrial-scale deployment, unlocking its potential for sustainable, carbon-neutral production and driving transformative advances in biotechnology.
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