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Published on: April 8, 2011
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Engineering Poly(lactic Acid)-Based Scaffolds for Abundant, Sustained, and Prolonged Lactate Release.
Pilar A Haro Gutiérrez1, Samuele Colombi1, Jordi Casanovas2
1IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany 10-14, Ed. I2, Barcelona 08019, Spain.
ACS Polymers Au
|June 16, 2025
Summary
This study developed a novel poly-(lactic acid) scaffold for sustained lactate release, promoting cardiac tissue regeneration. The engineered scaffold ensures prolonged release crucial for healing over 10-14 days.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background:
- Cardiac tissue regeneration requires sustained lactate levels for 10-14 days.
- Existing methods lack efficient, prolonged lactate delivery systems.
Purpose of the Study:
- To engineer a poly-(lactic acid) (PLA) scaffold for sustained lactate release.
- To achieve prolonged ( >10 days) and modulated lactate delivery for cardiac repair.
Main Methods:
- Fabrication of a five-layered electroresponsive scaffold using PLA microfibers, lactate, and PEDOT:PSS.
- Incorporation of plasma-treated, proteinase K-containing PLA microfibers for enzyme-mediated degradation.
- Electrostimulation and material surface modification to control release kinetics.
Main Results:
- Initial scaffold design provided lactate release over 3 days, enhanced by electrostimulation.
- Modified scaffold with enzyme-laden microfibers achieved sustained release for over 10 days.
- Release profile was successfully modulated by scaffold composition and treatment.
Conclusions:
- The developed PLA-based scaffold enables prolonged, tunable lactate release.
- This system holds potential for enhancing cardiac tissue regeneration therapies.
- The engineered scaffold offers a promising biomaterial for sustained drug/compound delivery.
