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Severe transient neonatal hyperinsulinism: First Peruvian case series

Manuel André Virú-Loza1, Francesca Bermudez-Paredes2, Isabel Milagros Arauco-Carhuas2

  • 1Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.

SAGE Open Medical Case Reports
|June 16, 2025
PubMed

Insights

Congenital hyperinsulinism causes severe hypoglycemia in children. Diazoxide effectively treated Peruvian infants with transient hyperinsulinism, showing manageable side effects.

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Medicine
  • Pharmacology

Background:

  • Congenital hyperinsulinism (CHI) is a leading cause of pediatric hypoglycemia, risking significant brain damage.
  • Transient forms of CHI, including those from perinatal stress, are common.
  • Diazoxide is the established first-line treatment for CHI.

Observation:

  • Reports on diazoxide use in Peruvian pediatric patients with hyperinsulinism are limited.
  • This study presents the first Peruvian case series of severe transient neonatal hyperinsulinism.
  • Patients were treated with diazoxide, a crucial medication for managing hyperinsulinism.

Findings:

  • The case series demonstrated a good response to diazoxide treatment in severe transient neonatal hyperinsulinism.
  • Adverse effects associated with diazoxide were manageable.
  • This highlights diazoxide's efficacy in the Peruvian pediatric population.

Implications:

  • Diazoxide is an essential medication for treating congenital hyperinsulinism.
  • Inclusion of diazoxide in Peru's national formulary is recommended for timely access.
  • This case series supports broader implementation of diazoxide therapy for pediatric hyperinsulinism in Peru.

Keywords:
diazoxidehyperinsulinismhypoglycemiainfantnewborn

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