Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolite biomarkers of screening neonatal congenital hypothyroidism based on dried blood spot metabolomics.

Analytical and bioanalytical chemistry·2025

Same author

Exploring the role of Life Essential 8 in patients diagnosed with systemic lupus erythematosus and rheumatoid arthritis.

Clinical rheumatology·2024

Same author

Sequential Tocilizumab and Tofacitinib Treatment for Systemic Juvenile Idiopathic Arthritis: a Case Report.

Rheumatology and therapy·2022

Same author

Decreased numbers and sex-based differences of circulating regulatory T cells in patients with seropositive undifferentiated arthritis.

Therapeutic advances in chronic disease·2021

Same author

Burden and depression in caregivers of patients with rheumatoid arthritis in China.

International journal of rheumatic diseases·2018

Same author

[Antibodies to mutated citrullinated vimentin and some associated autoantibodies in juvenile idiopathic arthritis].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2016

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

The sequential therapy for non-infectious scleritis: A case report.

Xiaoxiang Xie¹, Pan Jiang², Xuxu Li¹

¹Department of General Medicine, The Second Hospital of Shanxi Medical University (The Second Clinical Medical College of Shanxi Medical University, Shanxi Red Cross Hospital), Taiyuan, Shanxi, China.

SAGE Open Medical Case Reports

|June 16, 2025

Summary

This study presents a novel sequential treatment of tocilizumab and tofacitinib for non-infectious scleritis in a child, offering a new therapeutic option for this rare condition.

Keywords:

child non-infectious scleritis tocilizumab tofacitinib

More Related Videos

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

Warm Moxibustion and Scraping as a Traditional Chinese Medicine Therapy for Cervical Spondylosis Treatment

Warm Moxibustion and Scraping as a Traditional Chinese Medicine Therapy for Cervical Spondylosis Treatment

Published on: June 27, 2025

Related Experiment Videos

Last Updated: Sep 19, 2025

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

Warm Moxibustion and Scraping as a Traditional Chinese Medicine Therapy for Cervical Spondylosis Treatment

Warm Moxibustion and Scraping as a Traditional Chinese Medicine Therapy for Cervical Spondylosis Treatment

Published on: June 27, 2025

Area of Science:

Ophthalmology
Immunology
Pediatrics

Background:

Scleritis, an inflammatory scleral condition, can lead to severe vision loss and is often linked to systemic diseases.
Non-infectious scleritis in children is rarely reported, posing diagnostic and therapeutic challenges.
Conventional treatments like glucocorticoids may be effective but often result in disease recurrence.

Observation:

A pediatric case of non-infectious scleritis refractory to glucocorticoid therapy is detailed.
Extensive investigations excluded infectious etiologies for the scleritis.
The patient experienced disease recurrence during attempts to reduce glucocorticoid dosage.

Findings:

Sequential administration of tocilizumab followed by tofacitinib achieved successful disease remission.
The patient was weaned off glucocorticoids and all immunosuppressive therapy.
Complete drug cessation was maintained for two years post-treatment.

Implications:

This case highlights tocilizumab and tofacitinib as a potential effective treatment strategy for pediatric non-infectious scleritis.
The findings suggest a new diagnostic and treatment paradigm for clinicians managing this condition.
This approach may offer an alternative for patients unresponsive to or intolerant of conventional therapies.