Related Experiment Video
Updated: Sep 19, 2025
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
Published on: July 1, 2019
Optimising Paediatric Brain Mapping with Single-Pulse Transcranial Magnetic Stimulation: A New Protocol and Insights
Rudraksh Banga1, Aliya Mufti1, Suman Jain1
1Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Background:
Single-pulse paradigms of transcranial magnetic stimulation (TMS) have been used to understand cortical excitability and reorganisation.
Purpose:
This study aims to develop a protocol for mapping of the primary motor cortex (M1) using single-pulse TMS in children.
Methods:
A 11×11 manual grid was created around the hotspot of abductor pollicis brevis (APB). Motor-evoked potential (MEP) amplitude was recorded from 41 sites around the hotspot of APB and analysed.
Results:
Maximum MEP amplitude was recorded from the hotspot that reduced as distance increased. Heat maps generated were consistent among the participants.
Conclusion:
In children, 41 single-pulse TMS stimulations with interstimulus interval of two seconds provide reliable information about motor maps. This procedure will aid in understanding cortical reorganisation in children with neurodevelopmental disorders.
