Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.9K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.9K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

2.5K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
2.5K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.9K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.9K
Signal Transduction: Overview01:26

Signal Transduction: Overview

9.5K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
9.5K
Transmission Shafts: Problem Solving01:09

Transmission Shafts: Problem Solving

296
Designing a solid shaft that transmits power from a motor to a machine tool involves a series of calculations to ensure the shaft can withstand the stresses applied by bending moments and torques. First, calculate the torque exerted on the gear, considering the power transmitted by the shaft and its rotational speed. Following this, compute the tangential forces acting on the gears, which directly relate to the torque and the gear radius.
Next, use bending moment diagrams for the shaft to...
296

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-lived pauses reveal tunable kinetic barriers during Holliday junction migration.

Nucleic acids research·2026
Same author

Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production.

Nature nanotechnology·2026
Same author

The mechanical response of vinculin.

Science advances·2025
Same author

Structural Insights into the Force-Transducing Mechanism of a Motor-Stator Complex Important for Bacterial Outer Membrane Lipid Homeostasis.

Journal of the American Chemical Society·2025
Same author

Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats.

Nanoscale horizons·2025
Same author

PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence.

Science advances·2025

Related Experiment Video

Updated: Sep 19, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

7.1K

Decoding force-transmission linkages for therapeutic targeting and engineering.

Jingzhun Liu1, Yunxin Deng2, Jie Yan

  • 1Department of Physics, National University of Singapore, Singapore 117542, Singapore.

APL Bioengineering
|June 16, 2025
PubMed
Summary
This summary is machine-generated.

Cells sense and respond to mechanical forces via force-bearing linkages. This review explores these linkages as drug targets, using AI to refine mechanomedicine therapies.

More Related Videos

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

9.9K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.1K

Related Experiment Videos

Last Updated: Sep 19, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

7.1K
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

9.9K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.1K

Area of Science:

  • Cellular Mechanobiology
  • Biophysics
  • Molecular Medicine

Background:

  • Mechanosensing and mechanotransduction are crucial cellular processes.
  • Force-transmission supramolecular linkages mediate cellular responses to mechanical stimuli.
  • These linkages regulate signaling proteins and are implicated in disease pathways.

Purpose of the Study:

  • To review the mechanisms of force-bearing linkages in mechanosensing.
  • To explore the therapeutic potential of targeting these linkages.
  • To highlight the role of AI in advancing mechanomedicine.

Main Methods:

  • Review of existing literature on mechanosensing and mechanotransduction.
  • Analysis of force-transmission supramolecular linkage mechanisms.
  • Discussion of drug development and AI applications in protein engineering.

Main Results:

  • Force duration and mechanical structural changes in linkages are key regulatory factors.
  • Mechanosensing domains are activated or deactivated by these changes.
  • Emerging drugs and peptides show potential for modulating linkage properties.

Conclusions:

  • Force-bearing linkages represent promising pharmaceutical targets.
  • AI-driven protein engineering can enhance therapeutic precision in mechanomedicine.
  • Further research into these linkages will drive novel drug design and therapeutic strategies.