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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Updated: Sep 19, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Donor lung weight a novel predictor for primary graft dysfunction.

Andreas Martinsson1,2, Anders Thoren1,2, Sven-Erik Ricksten1,2

  • 1Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

JHLT Open
|June 16, 2025
PubMed
Summary
This summary is machine-generated.

Higher adjusted donor lung weight is linked to increased primary graft dysfunction (PGD) after lung transplantation. This finding suggests lung weight is a key factor in predicting early post-transplant outcomes.

Keywords:
Bilateral lung transplantationDonor lung weightICU stayPrimary graft dysfunctionTransplant complications

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Area of Science:

  • Thoracic surgery
  • Transplant immunology
  • Pulmonary medicine

Background:

  • Primary graft dysfunction (PGD) is a major cause of early death and complications after lung transplantation.
  • PGD involves lung injury and fluid buildup, often worsened by donor factors and surgical stress.
  • This study investigates donor lung weight as a predictor of PGD and transplant outcomes.

Purpose of the Study:

  • To determine if adjusted donor lung weight correlates with the incidence of primary graft dysfunction (PGD) after bilateral lung transplantation.
  • To identify adjusted donor lung weight as a potential risk factor for PGD and other early post-transplant outcomes.

Main Methods:

  • Retrospective analysis of 194 bilateral lung transplantations (2014-2021).
  • Donor lung weights were adjusted for body surface area and grouped into quartiles.
  • Primary outcomes included PGD incidence (grades II-III) and ICU stay duration.

Main Results:

  • Higher PGD incidence (22.9%) was observed in the highest lung weight quartile compared to lower quartiles (8.9%).
  • Adjusted donor lung weight was an independent risk factor for PGD.
  • Lower lung weight quartiles showed significantly higher rates of early extubation and shorter ICU stays.

Conclusions:

  • Adjusted donor lung weight is a significant predictor of PGD and early adverse outcomes in lung transplantation.
  • Incorporating donor lung weight into donor selection criteria may enhance recipient management and improve transplant success.