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Updated: Sep 19, 2025

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013
Atypical Presentation of Pancreatic Cancer Mimicking IgG4-Related Disease
Yazan Sallam1, Mir Zulqarnain2, Anas Al-Sadi1
1Internal Medicine, University of Missouri Kansas City, Kansas City, USA.
Abstract:
Pancreatic cancer often presents with vague, nonspecific symptoms such as painless jaundice, weight loss, and fatigue. Imaging can be diagnostic in pancreatic cancer. However, in rare cases, pancreatic cancer may present without a detectable mass, mimicking conditions like autoimmune pancreatitis (AIP). Supraclavicular lymph node metastasis, commonly associated with breast, lung, gastric, and esophageal cancers, is rarely reported in cases of pancreatic cancer. Even more unusual is the finding of an isolated Virchow's node in such cases. Here, we present a unique case of pancreatic adenocarcinoma characterized by an isolated, enlarged left supraclavicular lymph node without any clear evidence of a pancreatic mass on imaging.
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