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Updated: Sep 19, 2025
07:24
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
Published on: July 9, 2021
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Paraspeckle Component 1: a multifunctional RNA binding protein.
Minyan Hao1, Chandra Sugiarto Wijaya1, Linyao Lu1
1Department of Medical Oncology, Cancer Center of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310016, Zhejiang, China.
American Journal of Cancer Research
|June 16, 2025
Summary
Paraspeckle Component 1 (PSPC1) is crucial for many biological processes and is overexpressed in cancers. This review summarizes PSPC1
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Paraspeckle Component 1 (PSPC1) is a key protein in paraspeckles, involved in diverse cellular functions.
- PSPC1 plays critical roles in gene expression, DNA damage response, circadian rhythms, and spermatogenesis.
- The protein is implicated in cell fate determination and cancer metastasis.
Purpose of the Study:
- To provide a comprehensive review of the current research on PSPC1.
- To highlight the multifaceted roles of PSPC1 in normal biological processes.
- To discuss the significance of PSPC1 in cancer development and its potential as a therapeutic target.
Main Methods:
- Literature review of existing studies on PSPC1.
- Analysis of research on PSPC1 structure and function.
- Synthesis of data on PSPC1's involvement in various cancers.
Main Results:
- PSPC1 overexpression is observed in hepatocellular carcinoma, lung cancer, and breast cancer.
- PSPC1 actively contributes to tumorigenesis and cancer progression.
- The protein's role extends to cancer metastasis.
Conclusions:
- PSPC1 is a significant factor in multiple cancers, contributing to their development.
- Overexpressed PSPC1 presents potential as a biomarker for cancer detection.
- PSPC1 is a promising therapeutic target for various malignancies.
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