Organoid technology in cervical cancer research

Cervical cancer poses a serious threat to women's lives and health, and it may cause damage to the reproductive system, infertility, and even death. This study reviews the research progress of organoids in the treatment of cervical cancer. Studies have found that the culturing of tumor cell lines and the modeling techniques of tumor xenotransplantation for cervical cancer have certain limitations. Cervical cancer organoids are preclinical research models formed by culturing tumor cells derived from patients, which more accurately and effectively retain tumor heterogeneity, and also have the potential to take into account the interaction between tumor cells and the extracellular matrix. This article reviews the research on cervical cancer organoid models in the pathogenesis, drug screening, and precision medicine aspects in recent years, and then analyzes the development prospects and challenges of organoid technology in gynecological tumor research, in order to explore new possibilities for individualized treatment of cervical cancer.