Related Experiment Video

Updated: Aug 19, 2026

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

16.3K

Multiple cardiac papillary fibroelastomas: a case report and review of the literature

Mostafa Ali1, Mohammad Alomari1, Magdy M El-Sayed Ahmed1,2

  • 1Department of Cardiothoracic Surgery, Mayo Clinic, Jacksonville, FL, United States.

Frontiers in Cardiovascular Medicine
|June 16, 2025
PubMed

Insights

Cardiac papillary fibroelastomas (PFEs), rare tumors affecting both heart sides, can cause embolic events. Surgical resection of these benign cardiac tumors is effective for preventing further complications.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Oncology

Background:

  • Cardiac papillary fibroelastomas (PFEs) are the most common benign cardiac tumors, typically presenting as solitary lesions.
  • Multivalvular involvement of PFEs is exceptionally rare, with limited cases documented in medical literature.

Observation:

  • A 63-year-old male presented with embolic stroke symptoms and coronary artery embolism.
  • Echocardiography revealed multiple masses on both mitral and tricuspid valve leaflets.

Findings:

  • Successful valve-sparing surgical resection of the PFEs was performed, mitigating embolic risk.
  • Post-operative follow-up at 6 months showed no tumor recurrence and preserved valve function with minimal regurgitation.

Implications:

  • This case highlights the importance of considering rare presentations of PFEs, even with bilateral valvular involvement.
  • Valve-sparing surgery is a viable and effective treatment option for PFEs, preventing embolic complications and preserving cardiac function.

Keywords:
cardiac papillary fibroelastomascardiac surgerycardiac tumormanagement of heart tumorsvalvular abnormalities

More Related Videos

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition08:38

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

1.3K
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

83

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...