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The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating

Yuhu Lv1,2, Liyuan Chen1, Long Li3

  • 1College of Physical Education, Guangdong University of Education, Guangzhou, China.

Frontiers in Cardiovascular Medicine
|June 16, 2025
PubMed

Insights

Mitofusin 2 (MFN2) protein

Area of Science:

  • Cardiovascular research
  • Cell biology
  • Mitochondrial and ER interactions

Background:

  • Cardiovascular disease (CVD) is a major global health issue.
  • Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are crucial for organelle communication.
  • MAMs proteins are implicated in CVD pathogenesis.

Purpose of the Study:

  • To review current research on mitofusin 2 (MFN2).
  • To explore MFN2's role in myocardial protection via MAMs.
  • To discuss MFN2's involvement in various cardiovascular conditions.

Main Methods:

  • Literature review of MFN2 research.
  • Analysis of MFN2's function in MAMs.
  • Synthesis of findings on MFN2's cardioprotective potential.

Main Results:

  • MFN2 is a key protein in MAMs.
  • MFN2-mediated MAMs show potential in protecting against CVDs like ischemia/reperfusion injury, diabetic cardiomyopathy, and heart failure.
  • MFN2's diverse functions lead to controversial findings.

Conclusions:

  • MFN2 plays a significant role in myocardial protection through MAMs.
  • Further research is essential to elucidate MFN2's precise mechanisms in CVD.
  • Clarifying MFN2's function is critical for developing new CVD therapies.

Keywords:
cardioprotectioncardiovascular diseaseendoplasmic reticulummitochondriamitochondria-associated endoplasmic reticulum membranesmitofusin 2

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