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Narrative Review: A Neurobiological Perspective on Resilience in Youth
Kiran Khalid1, Huma Baqir2, Hanna E Stevens3
1Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
JAACAP Open
|June 16, 2025
Summary
Psychiatric resilience in youth is linked to brain structure and function. Understanding these neurobiological factors can help develop interventions to protect adolescent mental health from inherited or environmental risks.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Youth face risks for psychiatric morbidity from inherited and environmental factors.
- Resilience factors protect individuals from developing illness despite risk exposure.
- Research on resilience is crucial for understanding mental health protection and developing interventions.
Purpose of the Study:
- To explore the neurobiological underpinnings of resilience in youth.
- To identify brain-based methods for protecting mental health.
- To review neuroimaging studies on youth resilience from 2008-2023.
Main Methods:
- Narrative review of neuroimaging studies.
- Literature search from 2008 to 2023.
- Focus on youth with psychiatric risks.
Main Results:
- Resilience is associated with specific neurobiological features (anatomical, functional, genetic).
- Key brain regions include the hippocampus, amygdala, prefrontal and cingulate cortices, and white matter tracts.
- Involved networks and their functional/developmental aspects are crucial for understanding resilience.
Conclusions:
- Psychiatric resilience in youth involves multiple neurobiological and genetic factors.
- This knowledge can inform the identification and development of interventions.
- Targeting neurobiology is essential for effective prevention and intervention programs.
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