Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ibuprofen disposition in obese individuals.

D R Abernethy, D J Greenblatt

    Arthritis and Rheumatism
    |October 1, 1985
    PubMed
    Summary

    Obese individuals exhibit altered ibuprofen pharmacokinetics, with increased volume of distribution and clearance. This suggests higher ibuprofen doses may be needed in obese patients to reach therapeutic plasma concentrations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Response to diazepam in sons of alcoholics.

    Alcoholism, clinical and experimental research·1992
    Same author

    Benzodiazepine receptor binding of nonbenzodiazepines in vivo: alpidem, zolpidem and zopiclone.

    Brain research bulletin·1992
    Same author

    Mental illness, pharmacotherapy, and automobile operation: what is the risk?

    Journal of clinical psychopharmacology·1992
    Same author

    Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration.

    Journal of clinical pharmacology·1992
    Same author

    Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs.

    Journal of veterinary pharmacology and therapeutics·1992
    Same author

    Fluoxetine impairs clearance of alprazolam but not of clonazepam.

    Clinical pharmacology and therapeutics·1992

    Area of Science:

    • Pharmacology
    • Obesity Research
    • Clinical Pharmacy

    Background:

    • Obesity significantly impacts drug pharmacokinetics.
    • Understanding ibuprofen's behavior in obese individuals is crucial for effective pain management.

    Purpose of the Study:

    • To investigate the pharmacokinetic differences of ibuprofen in obese versus normal-weight individuals.
    • To determine how body weight affects ibuprofen distribution and clearance.

    Main Methods:

    • A pharmacokinetic study comparing 11 obese and 11 normal-weight subjects.
    • Oral administration of 600 mg ibuprofen after an overnight fast.
    • Measurement of peak concentration, time to peak, volume of distribution, clearance, and elimination half-life.

    Main Results:

    • Obese subjects showed decreased peak ibuprofen concentrations but unchanged time to peak.
    • Increased volume of distribution and clearance were observed in obese individuals, correlating with body weight.
    • Ibuprofen elimination half-life remained unchanged due to parallel increases in distribution and clearance.

    Conclusions:

    • Obesity alters ibuprofen pharmacokinetics, necessitating dose adjustments.
    • Increased ibuprofen doses, without changing the dosing interval, may be required in obese patients to achieve therapeutic plasma levels.
    • These findings support personalized dosing strategies for obese patients.

    Related Experiment Videos