Related Experiment Video
Updated: Sep 19, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Outcomes for Patients With Myeloid Neoplasms Treated With Chemotherapy Plus Venetoclax After Prior Venetoclax Therapy
Rafael Madero-Marroquin1, Joseph Cannova1, Emily Dworkin2
1Section of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Background:
Outcomes for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that have progression after treatment with hypomethylating agent (HMA) and venetoclax (VEN) are poor. However, data for chemotherapy and VEN (C+VEN) therapy after prior treatment with HMA+VEN are limited.
Methods:
We identified 18 patients with AML or MDS/AML who received C+VEN after prior HMA+VEN.
Results:
Complete remission (CR) or CR with incomplete hematologic recovery (CRi) was achieved in 7 patients (39%) and 6 patients (33%) proceeded to allogeneic hematopoietic stem cell transplantation.
Conclusion:
This study shows suggests that C+VEN could be a viable option in a subset of patients after HMA+VEN.
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