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Methods of reducing fever

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Pharmacological Methods of Reducing Fever:

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Related Experiment Video

Updated: May 10, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.

Rebeca Ferreira Dias¹, Sarah de Lima Silva¹, Sophia Parreira de Mello¹

¹The State University of Western Paraná (UNIOESTE), Cascavel, Brazil.

Pain Practice : the Official Journal of World Institute of Pain

|June 16, 2025

Summary

Cryotherapy may help reduce knee osteoarthritis pain and improve function when combined with other therapies. More research is needed to confirm its effectiveness as a standalone treatment for knee pain.

Keywords:

cryotherapy knee osteoarthritis systematic review

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Last Updated: May 10, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

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Published on: April 26, 2024

Area of Science:

Orthopedics and Sports Medicine
Rehabilitation Science
Pain Management

Background:

Knee osteoarthritis (OA) is a prevalent degenerative joint disease causing pain and functional limitations.
Current management strategies for knee OA often involve a multimodal approach.
Cryotherapy is a therapeutic modality with potential analgesic and anti-inflammatory effects.

Purpose of the Study:

To synthesize current evidence on the efficacy of cryotherapy for knee osteoarthritis.
To evaluate cryotherapy's impact on pain reduction, strength enhancement, and functional improvement in knee OA patients.

Main Methods:

A systematic literature search was conducted across multiple databases (PubMed, Embase, Cochrane, PEDro, Scopus, Web of Science, LILACS) and gray literature sources.
Risk of bias was assessed using the Cochrane RoB 2 tool by two independent reviewers.
Meta-analysis was performed for pain intensity and functionality outcomes.

Main Results:

Five randomized controlled trials involving 2094 participants were included.
Cryotherapy demonstrated a statistically significant reduction in pain intensity (SMD: -0.57, p=0.004).
A trend towards improved functionality was observed, though not statistically significant (SMD: -0.28, p=0.07).

Conclusions:

Cryotherapy shows promise as an adjunct therapy for knee osteoarthritis, particularly when integrated with kinesiotherapy.
Further high-quality studies with a lower risk of bias are warranted to establish cryotherapy's standalone efficacy in managing knee OA.