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Related Experiment Video

Updated: Sep 19, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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NMDA-Dependent Coplasticity in VIP Interneuron-Driven Inhibitory Circuits.

Jadwiga Jabłońska1, Grzegorz Wiera1, Jerzy W Mozrzymas1

  • 1Department of Biophysics and Neuroscience, Wroclaw Medical University, Wroclaw, Poland.

Journal of Neurochemistry
|June 16, 2025
PubMed
Summary

This study explores inhibitory plasticity (I→I) in hippocampal circuits, revealing target cell-specific mechanisms. Vasoactive intestinal peptide (VIP) interneurons modulate excitation/inhibition (E/I) balance through unique plasticity patterns.

Keywords:
GABANMDAVIPcoplasticityiLTPinhibitory plasticityinhibitory synapseparvalbuminplasticitomesomatostatin

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Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Computational Neuroscience

Background:

  • Inhibitory plasticity regulates excitation/inhibition (E/I) balance, crucial for brain network dynamics.
  • Plasticity at interneuron-interneuron (I→I) synapses is less understood than at excitatory targets.
  • Vasoactive intestinal peptide (VIP) interneurons play a role in local circuit modulation.

Purpose of the Study:

  • To investigate the properties and plasticity of inhibitory inputs from VIP interneurons onto stratum oriens interneurons (soINs) in the hippocampal CA1 region.
  • To characterize subtype-specific long-term plasticity at VIP→soIN synapses.
  • To examine the coplasticity of inhibitory and excitatory inputs onto soINs.

Main Methods:

  • Optogenetics for targeted synaptic stimulation.
  • Patch-clamp electrophysiology to record synaptic currents.
  • Morphological reconstructions for cell characterization.
  • NMDA receptor activation protocols to induce plasticity.

Main Results:

  • VIP→soIN synapses exhibit target cell-specific kinetics and NMDA receptor-dependent long-term depression (iLTD).
  • Brief NMDA activation induced long-term potentiation (LTP) at excitatory inputs (E→I) but iLTD at inhibitory inputs (I→I) onto OLM/bistratified cells.
  • FS interneurons showed duration-dependent coplasticity patterns between I→I and E→I synapses.

Conclusions:

  • VIP interneurons exhibit target cell-specific inhibitory plasticity, influencing E/I balance.
  • The interplay between inhibitory and excitatory plasticity is dynamically regulated.
  • These findings highlight VIP interneurons as key regulators of hippocampal E/I balance.